Product Name:Acorcin-425

Composition: Nimuslide 100 mg + Paracetamol 325 mg

Nimesulide is a nonsteroidal arylsulfonamide with anti-inflammatory properties. Nimesulide inhibits the cyclooxygenase-mediated conversion of arachidonic acid to pro-inflammatory prostaglandins. Modestly selective for COX-2, this agent binds to the enzyme, thereby inactivating it. Nimesulide may inhibit some carcinogenic COX-2-related carcinogenic effects on xenobiotic metabolism, apoptosis, immune surveillance and angiogenesis.

Paracetamol (acetaminophen) is a pain reliever and a fever reducer. Paracetamol is used to treat many conditions such as headache, muscle aches, arthritis, backache, toothaches, colds, and fevers.

Indications:

• Arthritis
• Acute musculoskeletal disorder
• Low back pain
• Sports injuries
• Severs dental pain
• Gynecological conditions

Pharmacokinetics:

1. Nimuslide

Nimuslide is fairly rapidly absorbed from the gastrointestinal tract. The volume of distribution in the post distribution phase for Nimuslide ranges from 0.19 to 0.39 L/Kg, indication that the drug is principally distributed in the extra cellular fluid compartment. Nimuslide is almost exclusively metabolized & cleared by the liver. After oral administration of Nimuslide 100 mg the apparent mean elimination half life varied from 1.96 to 4.75 hrs. Nimuslide is mainly eliminated by the renal route.

2. Paracetamol

• Absorption: Paracetamol is rapidly and completely absorbed after oral administration.
• Distribution: It is distributed mostly in the body in unbound form.
• Metabolism: It is extensively metabolized in the liver.
• Excretion: Excreted in the urine.

Side effects:

Nausea
Diarrhea
Head ache
Vomiting
Constipation
Abdominal pain
Sweating
Dry mouth

Contraindications:

• Severe renal failure
• Peptic ulcer disease

Warning & Precautions:

• Caution should be exercised in patients with history of stomach problem, high blood pressure, fluid retention, elderly, during pregnancy & breast feeding.

Other Precaution:

• Avoid excess dosage.