Product Name:Levoclair Tablet

Composition: Levofloxacin 500 mg

Levofloxacin is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class and is used to treat severe or life-threatening bacterial infections or bacterial infections which have failed to respond to other antibiotic classes. It is sold under various brand names, such as Levaquin and Tavanic, the most common. In form of ophthalmic solutions it is known as Oftaquix, Quixin and Iquix.

Indications:

• Typhoid
• Pneumonia
• Bronchitis
• Skin & Soft tissue infection
• Bone & joints infections

Pharmacokintics:

Levofloxacin exerts antibacterial action by inhibiting bacterial topoisomerase IV and DNA gyrase, the enzymes required for DNA replication, transcription repair and recombination. It has in vitro activity against a wide range of gram-negative and gram-positive microorganisms.

Rapid and complete absorption from the GIT (oral); peak plasma concentrations within 1-2 hr.

Widely distributed in bronchial mucosa, lungs; CSF (relatively poor). Protein-binding: 30-40%.

Limited.

Mainly via urine (largely as unchanged drug); 6-8 hours (elimination half-life).

Levofloxacin Adverse Reactions / Levofloxacin Side Effects:

Nausea, diarrhoea, constipation, headache, insomnia, inj site reactions (IV). Ophthalmic: Transient decrease in vision, ocular burning, ocular pain or discomfort, foreign body sensation, headache, fever, pharyngitis, photophobia.

Side Effects:

• Diarrhea
• Loose or frequent stools
• Abdominal pain
• Nausea
• Stomach upset

Contraindications:

• Hypersensitivity to Cephalosporin
• Along with Carbamazepine