Product Name:Levohold Tablet

CComposition: Levocetirizine 5 mg

Levocetirizine (as levocetirizine dihydrochloride) is a third-generation non-sedative antihistamine, developed from the second-generation antihistamine cetirizine. Chemically, levocetirizine is the active enantiomer of cetirizine. It is the L-enantiomer of the cetirizine racemate. Levocetirizine works by blocking histamine receptors. It does not prevent the actual release of histamine from mast cells, but prevents it binding to its receptors. This in turn prevents the release of other allergy chemicals and increased blood supply to the area, and provides relief from the typical symptoms of hayfever.

Indications:

• Seasonal allergic rhinitis
• Perennial allergic rhinitis
• Chronic idiopathic urticaria
• Acute allergic reaction due to drugs, food & insect bites
• Non sedating long action H1 receptor antagonist antihistamine of second generation
• Does not cause impairment in CNS function.

Pharmacokinetics:

• Levocetirizine, an active isomer of cetirizine, selectively inhibits histamineH1-receptors.
• Absorption Rapidly and extensively absorbed from the GI tract (oral); peak plasma concentration in 0.9 hours.
• Distribution Protein-binding:91-92%.
• Metabolism Via aromatic oxidation, N- and O-dealkylation and taurine conjugation.
• Excretion Via urine (85.4%), via faeces (12.9%), as metabolites and unchanged drug; 8 hours (plasma half-life).

Mechanism of Action:

Levocetirizine, the active enantiomer of cetirizine, is an antihistamine; its principal effects are mediated via selective inhibition of H1 receptors. The antihistaminic activity of levocetirizine has been documented in a variety of animal and human models.

Side Effects:

• Fatigue
• Somnolence
• Dry mouth
• Nasopharyngitis
• Pyrexia
• Cough
• Epistaxis

Contraindications:

Hypersensitivity, pregnant patients, patient with blood & lymphatic systemic disorder & psychiatric disorder.