Product Name:Allevpod-200 Tablet

Composition: Cefpodoxime 200 mg

Cefpodoxime is orally administered, extended spectrum, semi synthetic, antibiotic of the Cephalosporin class. It is given as a Cefpodoxime is a pro drug which is absorbed. It is active against most gram positive & negative bacteria.

Indications:

• Pharyngitis and/or tonsillitis
• Community-acquired pneumonia
• Acute bacterial exacerbation of chronic bronchitis
• Acute, uncomplicated urethral and cervical gonorrhea
• Acute, uncomplicated ano-rectal infections in women
• Uncomplicated skin and skin structure infections

Mechanism of Action:

Cefpodoxime is a bactericidal agent that acts by inhibition of bacterial cell wall synthesis. Cefpodoxime has activity in the presence of some beta-lactamases, both penicillinases and cephalosporinases, of Gram-negativeand Gram-positive bacteria.

Pharmacology:

Absorption and Excretion:

Cefpodoxime Proxetil is a prodrug that is absorbed from the gastrointestinal tract and de-esterified to its active metabolite, cefpodoxime. Following oral administration of 100 mg of Cefpodoxime Proxetil to fasting subjects, approximately 50% of the administered cefpodoxime dose was absorbed systemically. Over the recommended dosing range (100 to 400 mg), approximately 29 to 33% of the administered cefpodoxime dose was excreted unchanged in the urine in 12 hours. There is minimal metabolism of Cefpodoxime.

Distribution:

Protein binding of cefpodoxime ranges from 22 to 33% in serum and from 21 to 29% in plasma.

Adverse Effect:

• Upset stomach
• Diarrhea
• Vomiting
• Mild skin rash

Warning & Precautions :

Before taking Cefpodoxime:

• Tell your doctor & pharmacist, if you are allergic to Cefpodoxime or any other Cephalosporin antibiotics.
• Tell your doctor & pharmacist what prescription & non prescription medcation you are talking, especially other antibiotics, anticoagulant.
• Tell your doctor if you have or have ever had kidney or liver disease, colitis or stomach problem.
• Tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you are having surgery, including dental surgery, tell the doctor or dentist that you are taking Cefpodoxime