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Ofloxacin is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class considered to be a second generation fluoroquinolone.
Ornidazole is a drug that cures some protozoan infections & prophylaxis of anaerobic bacterial infections. It is an antimicrobial agent for the treatment of infections due to trichomonads, amoebae, giardia lamblia & anaerobic bacteria.
Ofloxacin is a fluoroquinolone antibiotic, which interferes with the bacterial DNA synthesis via inhibition of the DNA gyrase or topoisomerase II. Fluoroquinolone antibiotics are bactericidal.
Ornidazole is a nitro imidazole which has broad spectrum cidal activity against Protozoa and some anaerobic bacteria. Its selective toxicity to anaerobic microbes involves 1. Drug enters the cell by diffusion, 2. Nitro group of drug is reduced by redox proteins present only in anaerobic organisms to reactive nitro radical which excerts cytotoxic action by damaging DNA and other critical biomolecules. 3. DNA helix destabilization &strand breakage has been observed.
Ornidazole reduce the nitro group to more reactive amine groups that interrupt with the formation of microbial DNA. The action of Ornidazole results in loss of helical structure and DNA breakdown.
Ofloxacin inhibits the formation of bacterial DNA gyrase. Ofloxacin is effective against Mycobacterium species including M. leprae, M. tuberculosis and Chlamydia trachomatis.
Ofloxacin + Ornidazole is contraindicated in patients with blood dyscrasias, neurological disorders, hepatic disorders, suspected CNS disorders.
