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Methylcobalamin, an analogue of vitamin B12, is prescribed for the prevention and treatment of vitamin B12 deficiency, memory loss, psoriasis, pernicious anemia, homocysteinemia, atopic dermatitis and age-related macular degeneration. Methylcobalamin is either prescribed as a monotherapy or as a combined therapy with other nutritional supplements including pyridoxine, folic acid and avocado oil.
Methylcobalamin is a cobalamin (MeB12) used in peripheral neuropathy, diabetic neuropathy etc. It is a form of vitamin B12. This vitamer is one of two active coenzymes used by B-12 dependent enzymes in the body, and is specifically the B-12 form used by 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR), also known as methionine synthase. It is used in treating diseases of vitamin B12 deficiency (such as pernicious anemia), or diseases of effective B12 deficiency, such as vitamin B12 metabolic pathway pathologies. One study suggests that once absorbed, methylcobalamin may be retained in the body better than cyanocobalamin.
Methylcobalamin or Mecobalamin is the neurologically active form of vitamin B12 and occurs as a water-soluble vitamin in the body. It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl groups for the regeneration of methionine from homocysteine. In anaemia, it increases erythrocyte production by promoting nucleic acid synthesis in the bone marrow and by promoting maturation and division of erythrocytes.
Methylcobalamin and Pregnancy
In recommended doses, Methylcobalamin is likely safe during pregnancy. Methylcobalamin and Lactation
In recommended doses, Methylcobalamin is likely safe during lactation. Methylcobalamin and Children
The dosage and duration should be based on the patient’s condition and requirement
