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Levocetirizine (as levocetirizine dihydrochloride) is a third-generation non-sedative antihistamine, developed from the second-generation antihistamine cetirizine. Chemically, levocetirizine is the active enantiomer of cetirizine. It is the L-enantiomer of the cetirizine racemate. Levocetirizine works by blocking histamine receptors. It does not prevent the actual release of histamine from mast cells, but prevents it binding to its receptors. This in turn prevents the release of other allergy chemicals and increased blood supply to the area, and provides relief from the typical symptoms of hayfever
Montelukast is used to prevent wheezing, difficulty breathing, chest tightness, and coughing caused by asthma. Montelukast is also used to prevent bronchospasm (breathing difficulties) during exercise. Montelukast is also used to treat the symptoms of seasonal (occurs only at certain times of the year), and perennial (occurs all year round) allergic rhinitis (a condition associated with sneezing and stuffy, runny or itchy nose). Montelukast is in a class of medications called leukotriene receptor antagonists (LTRAs). It works by blocking the action of substances in the body that cause the symptoms of asthma and allergic rhinitis.
Montelukast+Levocetirizine a combined therapy is prescribed for the systemic treatment of allergic reactions such as chronic urticaria, obstructive airway diseases and rhinitis. Montelukast belongs to leucotriene receptor antagonist.
Levocetirizine, the active enantiomer of cetirizine, is an antihistamine; its principal effects are mediated via selective inhibition of H1 receptors. The antihistaminic activity oflevocetirizine has been documented in a variety of animal and human models.
Montelukast blocks the action of leukotriene D4 on the cysteinyl leukotriene receptor CysLT1 in the lungs and bronchial tubes by binding to it. This reduces the bronchoconstriction otherwise caused by the leukotriene, and results in less inflammation.
Montelukast + Levocetirizine is contraindicated in patients with an allergy to either or both drugs, hepatic impairment, NSAID allergy, Churg-Strauss syndrome.
Montelukast + Levocetirizine is contraindicated in children less than six months of age.
Montelukast + Levocetirizine can cause dizziness. Do not drive vehicles or operate heavy machineries that need alertness.
Hypersensitivity, pregnant patients, patient with blood & lymphatic systemic disorder & psychiatric disorder.
