Product Name: Alivfen Inj.

Composition:(Diclofenac sodium 75 mg/1 ml) (Aqueous base)

Diclofenac (marketed as Voltaren and under a number of other trade names, see below) is a non-steroidal anti-inflammatory drug (NSAID) taken to reduce inflammation and as an analgesic reducing pain in conditions such as arthritis or acute injury. It can also be used to reduce menstrual pain, dysmenorrhea. The name is derived from its chemical name: 2-(2,6-dichloranilino)phenylacetic acid.

In the United Kingdom, India, and the United States, it may be supplied as either the sodium or potassium salt, in China most often as the sodium salt, while in some other countries only as the potassium salt. Diclofenac is available as a generic drug in a number of formulations. Over the counter (OTC) use is approved in some countries for minor aches and pains and fever associated with common infections.

Indications:

• Powerful relief of pain & inflammatory
• Excellent Tolerability
• High vascular/renal safety profile.
• Acute muscle spasm
• Lower back pain

Pharmacokinets of Diclofenac:

• Absorption- It is rapidly and completely absorbed after oral administration
• Distribution- Widely distributed in the body as protein-bound form. It is highly protein-bound (>99.7%). Aceclofenac penetrates into the synovial fluid, where the concentrations reach approximately 60% of those in plasma.
• Metabolism- Metabolized into metabolites in the liver. Main metabolite is 4-hydroxyaceclofenac
• Excretion- It is excreted through urine mainly as conjugated hydroxymetabolites

Pharmacodynamics:

Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID). In pharmacologic studies, Diclofenac has shown anti-inflammatory, analgesic, and antipyretic activity. As with other NSAIDs, its mode of action is not known; its ability to inhibit prostaglandin synthesis, however, may be involved in its anti-inflammatory activity.

Side Effects:

• Nausea
• Diarrhea
• Rashes
• Vomiting
• Constipation
• Abdominal pain

Contraindications:

• Hypersensitivity to Paracetamol.
• Blood coagulation disorder.

Special Precautions while taking:

• Blood disorder
• Stomach disorder
• Hypertension
• Hepatic failure

Storage:

• Store it at room temperature (25˚C) & Protect from light & moisture.