Product Name:Acorzone-CS 1.5 gm Inj.

Composition:Cefoperazone 1000 mg & Sulbactam 500 mg

Cefoperazone is a third generation cephalosporin antibiotic. It is one of few cephalosporin antibiotics effective in treating Pseudomonas bacterial infections which are otherwise resistant to these antibiotics. Sulbactam is a β-lactamase inhibitor. This drug is given in combination with β-lactam antibiotics to inhibit β-lactamase, an enzyme produced by bacteria that destroys the antibiotics.

Indications:

• Respiratory Tract Infection
• Gastrointestinal infection
• Gynecological
• Surgical prophylaxis
• UTI

Pharmacodynamics:

Cefoperazone binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.

Pharmacokinetics:

Distribution: Widely distributed into body tissues and fluids; poor CSF penetration. Crosses the placenta and enters breast milk (low concentrations); bile (high concentrations). Protein-binding: 82-93%

Excretion: Mainly via the bile. Via the urine within 12-24 hrs by glomerular filtration (30% as unchanged); proportion may be increased in hepatic or biliary disease.

Mechanism of action:

Cefoperazone, a third-generation cephalosporin, interferes with cell wall synthesis by binding to.the penicillin-binding proteins (PBPs), thus preventing cross-linking of nascent peptidoglycan. Cefoperazone is stable to penicillinases and has a high degree of stability to many beta-lactamases produced by gram-negative bacteria.

Sulbactam is a semi-synthetic beta-lactamase inhibitor. The beta-lactam ring of sulbactam irreversibly binds to beta-lactamase at or near its active site, thereby blocking enzyme activity and preventing metabolism of other beta-lactam antibiotics by the enzyme. Combining this agent with a beta-lactamase susceptible antibiotic, such as penicillins or a cephalosporin, to treat infections caused by beta-lactamase producing organisms, results in a decreased turnover rate of the beta-lactamase sensitive antibiotic and enhances its antibacterial activity.

Side Effects:

• Superinfection
• Anaphylaxis
• Diarrhea
• blood dyscrasias
• Rash
• Fever
• GI effect

Special Precautions:

Pregnancy, lactation

Other Drug Interactions:

With aminoglycosides: Concomitant admin may increase risk of nephrotoxicity.

With heparin/warfarin: Concurrent use may cause marked hypoprothrombinemia and/or prolonged bleeding time.

Storage:

Store at room temperature 25̊C.